MUSCLE STEM CELL Research

  Research Areas


stem cell

Confocal images of satellite cell (arrows), image was taken with Olympus FV-1000 microscope.


Satellite cell is the resident muscle stem cell responsible for the development of muscle during embryonic stage. These cells remain in adult as quiescent stem cell and play an important role in muscle regeneration after various type of muscle injuries including physical trauma and toxin/chemical-induced muscle injury. The evidence supporting this role of satellite cell is currently well-established. Genetic ablation study using inducible Cre-Lox system revealed an essential role of satellite cells as demonstrated by the severe impairment of muscle regeneration. However, the underlying mechanisms by which satellite cell activities are regulated still not clearly understood. In addition, the contribution of satellite cell on the muscle plasticity such as muscle hypertrophy is still ambiguous.

 

Our interest is on the regulation of satellite cell activity after contusion/myotoxin-induced muscle injuries and during the response to overloading stimuli that induces muscle hypertrophy. In addition, the changes of muscle function, an alteration of gene expression, and the downstream signaling pathways of the agents that enhance satellite cell activation, proliferation, and differentiation are the main targets for our investigations. Both cell culture and animal (mouse and rat) models are used to elucidate possible new therapeutic agents that would help enhancing the activity of muscle stem cells and hence increasing the rate of muscle recovery. Furthermore, the changes of satellite cell activity and fiber type distribution during specific training regimen in horses are under investigated

chemical   contusion
     
 
cell
regeneration

 

 

muscle1 muscle2
   
metha
metha2

 

     
Members in the Research Group
Staff :
   
ton  

Assis.Prof. Dr.Ratchakrit Srikuea (Principle Investigator)

Students :    
nat   Miss Kanokwan Suhatcho
metha   Mr. Metha Chanda