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Research Activities
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Receptor pharmacology, signal transduction Current research of
this laboratory focus on the functions of estrogen receptors on immune
cells and the roles of estrogen in autoimmune diseases, the activities
are also compared with phytoestrogens, a potential alternative to
estrogens. This work includes the search for the mechanisms of
signaling pathways and how these signaling pathways relate to human
diseases.Room B513 |
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Osteoarthritis is a common inflammatory disease in elderly people (e.g. > 30 of Thai people over age of 65 yr). Because of the risk associated with the use of NSAIDs in these patients, The option of complementary and alternative medicine (CAM), such as acupuncture and medicinal herbs, are selected as alternative therapies for most OA patients. We search for the herbs with anti-inflammatory or anti- arthritic properties with a safe and effective adjunction therapeutic approach for the treatment of OA patients. Current herbs under study are Derris Scandens and Ananas Comosus. The mechanism of action of these two medicinal herbs were investigated. Many equipment such as platelet aggregometer, HPLC, PCR, Elisa and NO detector etc are used for these purposes. Room B513A |
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Cardiovascularpharmacology & Immunopharmacology The laboratory is located at
Pr.505. The main research interests are focused on the
investigation of myocardial infarction and endothelial and vascular
function, also examining the underlying mechanisms involved in
inflammation and ischemia reperfusion injury. Many techniques are used
and include, in vivo animal model, isolated heart model (Langendorf
model), myography and platelet aggregation. |
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Free radical reactions
involve in pathogenesis of several diseases. Our laboratory develops
and utilizes the advance technique especially electron paramagnetic
resonance (EPR) spectroscopy to characterize free radical reactions
mainly in iron overload and thalassemia syndrome as well as other
oxidative related diseases. Pharmacology of iron chelators is also a
line of our research. Room B507. |
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Laboratory for neuroprotective aspects of Thai medicinal plants Our lab is interested in the neuroprotective aspects of Thai medicinal plants, such as Curcuma longa, Curcuma comosa, and Moringa oleifera, these are known to have anti-oxidant and anti-inflammatory properties. Oxidative stress and neuroinflammation resulting from chronic activation of microglia have been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer’s disease and Parkinson’s disease. Two in vitro models of neurodegeneration are studied in the lab: the first model uses a neurotoxin specific to dopaminergic neurons to induce neurotoxicity in dopaminergic cell lines; the second model uses lipopolysaccharide (LPS) to induce microglial activation. Our current focus is on identifying signaling pathways involved in the neuroprotective effects of the crude extracts and pure compounds isolated from the medicinal plants. In the future, we will expand our studies of neurodegenerative diseases to incorporate advanced molecular biology techniques and topics, such as microarray profiling, RNA interference, lentiviral vector expression, and stem cell therapeutics. |
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Laboratory for nitric oxide and malaria research Our interest is focused on biology of nitric oxide and its metabolites including dysregulation of nitric oxide metabolism in diseases including thalassemia and malaria. Nitric oxide is primary measured by the chemiluminescence methods. In addition, we have cultured the malarial parasite as resource for further studies on interactions of antimalarial drugs and nitric oxide in malaria-infected red blood cells. Room B511. |
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