Lect. Dr. Pornthip  Chaichompoo    
Department of Pathobiology,
Faculty of Science, Mahidol University
272 Rama VI Road, Phayathai
Ratchathewi, Bangkok 10400, THAILAND
Tel: 662-201-5577
Fax: 662-354-7158
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2004          Bachelor of Science (Medical Technology)
                  Faculty of Associated Medical Sciences, Chiang Mai University

2007          Master of Science (Immunology)
                  Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University

2010          Ph.D (Immunology)
                  Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University



Microparticles and pathophysiology in thalassemia

        Rationale and Research Methodology: Thalassemia is a commonly genetic disease in Thailand as 20-30% α-thalassemia
and 3-9% β-thalassemia (~13% of population is combined with Hb E). The couples in Thailand are ~5.6% of risk to giving
birth to babies with severe hemoglobinopathies; Hb Bart’s hydrops fetalis, Hb H disease, homozygous β-thalassemia,
and β-thalassemia/Hb E. Although the molecular defects of both α- and β-globin genes have been defined, the
consequences of multiple gene-to-gene interactions in order to the understanding of mechanism/severity in patients
are still unclear. The imbalance of globin chain synthesis in thalassemic erythroid cells leads to denaturation and
degradation of excess unbounded globin with associated with high amounts of reactive oxygen species (ROS) but low
level of antioxidant in erythroid cells. There have been several proposed that the effects of ROS play an important role
on cell division and proliferation, risk to cell death, cytoskeleton membrane disruption, loss of plasma membrane
asymmetry and one of factors to membrane vesiculation (microparticles, MP).
        MPs display the cell surface proteins and biological molecules (miRNA, RNA, DNA and some chemical agents) of multiple
parent cell types including platelets, RBCs, endothelial cells, lymphocytes, monocytes and granulocytes. The physiological
roles of MPs are derived into 3 major topics: coagulation, inflammation and endothelial dysfunction. In thalassemia,
patientshad high levels of circulating membrane-derived MPs with high risk to thromboembolic events. However, mechanism
and biological effects of MP in thalassemia are still unclear. Therefore, both thalassemic patients and mice are a good model
for basic research to understand the pathophysiology in thalassemia and also develop to therapeutics.



1. Co-investigator: “Role of miRNA in thalassemia disease severity” was supported by Research Chair Grant, National
    Science and Technology Development Agency (NSTDA) (2011-2016)

2. Co-investigator: “Functional genomic approach for candidate gene intervention in the thalassemic iPS cells” was
    supported by NRCT-JSPS Joint Research Program, National Research Council of Thailand (2013-2016)

3. Co-investigator: “A novel immunotherapy to ovarian and colon cancer” was supported by Research institutional
    development in sciences and technology, The Thailand Research Fund (TRF) and Faculty of Science,
    Mahidol University (2012-2017)

4. Principle investigator: “Effects of platelet-derived microparticles on endothelial dysfunction in thalassemia” was
    supported by Mahidol University Research Grants and Faculty of Science, Mahidol University (2015-2016)



June 2004 - May 2006                 Siriraj Graduate Scholarship, Faculty of Medicine Siriraj hospital, Mahidol University,

June - September 2006              Partial Thesis Scholarship, Faculty of Medicine Siriraj hospital, Mahidol University,

June 2007 - March 2010              The Royal Golden Jubilee Ph.D. Program, Thailand Research Fund, Thailand.

August 2010                                The Japan Society for the Promotion of Sciences (JSPS) Program

September 2010 - August 2011   The 1st Postdoctoral Mahidol University, Bangkok, Thailand
                                                   Title “Telomere length and erythrocyte senescence in thalassemia”

October - December 2011           Junior Research Fellowship Program 2011 (French Embassy)

October 2011- June 2012            Postdoctoral fellow at iMETI/CEA, Paris, France
                                                   Title “Generation of hematopoietic stem cells from cynomolgus IPSCs” and “Human
                                                   Bmi1 overexpression in human CD34 positive cells improve hematopoietic progenitor cell
                                                   production and engraftment in NSG mice model”

July 2012 - June 2013                  The 2nd Postdoctoral Mahidol University, Bangkok, Thailand
                                                    Title “Telomere length and erythrocyte senescence in thalassemia”


1. Pattanapanyasat K, Gonwong S, Chaichompoo P, Noulsri E, Lerdwana S, Sukapirom K, Siritanaratkul N, Fucharoen S.
    Activated platelet-derived microparticles in thalassaemia. Br J Haematol. 2007 Feb;136(3):462-71.
    (Impact Factor: 2007: 4.490)

2. Chaichompoo P, Bostik P, Kobkitjaroen J, Stephenson S, Udompunturuk S, Pattanapanyasat K, Ansari AA. Multiple
    KIR gene polymorphisms are associated with plasma viral loads in SIV infected rhesus macaques. Cellular Immunol.
    2010 Apr;263(2):176-87. (Impact Factor: 2010: 2.575, 5-Year Impact Factor: 2010: 2.333)

3. Chaichompoo P, Kumya P, Khowawisetsut L, Chiangjong W, Chaiyarit S, Pongsakul N, Sirithanaratanakul N, Fucharoen S,     
    Thongboonkerd V, Pattanapanyasat K. Characterizations and proteome analysis of platelet-free plasma-derived
    microparticles in β-thalassemia/haemoglobin E patients. J Proteomics. 2012 Dec;5(76):239-50.
    (Impact Factor: 2012: 4.088, 5-Year Impact Factor: 2012: 4.302)

4. Keawvichit R, Khowawisetsut L, Chaichompoo P, Polsrila K, Sukklad S, Sukapirom K, Khuhapinant A, Fucharoen S,
    Pattanapanyasat K. Platelet activation and platelet-leukocyte interaction β-thalassemia/haemoglobin E patients
    with marked nucleated erythrocytosis. Ann Hematol. 2012 Nov;91(11):1685-94.
    (Impact Factor: 2012: 2.866, 5-Year Impact Factor: 2012:2.635)

5. Chaichompoo P, Pattanapanyasat K, Winichagoon P, Fucharoen S, Svasti S. Accelerated telomere shortening in beta-
    thalassemia/HbE patients. Blood cells, molecules & diseases. 2015 Jan 17. PubMed PMID: 25631622.
    Epub 2015/01/30. Eng.
Department of Pathobiology, Faculty of Science, Mahidol University,
  Rama VI Road, Bangkok 10400, Thailand.
  Phone : (662) 201-5550, 354-7158  Fax : (662) 354-7158,,