Dr. Skorn Mongkolsuk

Group : Molecular and Medical Biotechnology

Contact Details :

Laboratory of Biotechnology
Chulabhorn Research Institute
Vibhavadee Rangsit Highway, Laksi, Bangkok 10210 THAILAND
Tel : 0-2574-0622 Fax : 0-2571-0627
E-mail : scsmk@mahidol.ac.th

Position Held :

	1987-1991	Lecturer, Department of Microbiology, Mahidol University
	1990-present	Head, Laboratory of Biotechnology, Chulabhorn Research Institute
	1991-1998	Assistant Professor, Department of Biotechnology, Mahidol University.
	1998-2002	Associate Professor, Department of Biotechnology, Mahidol University.
	1998-2002	Associate Faculty Member, Asian Institute of Technology.
	2002-present	Professor of Biotechnology, Department of Biotechnology, Mahidol University.
	2002-present	Adjunct Professor, Asian Institute of Technology
	2002-present	Associate Dean for Integrated Research, Faculty of Science, Mahidol University

Research Interest :

Bacterial Molecular genetic and bacterial physiology of stress response

Education :

	1977-1980	University of London, B.Sc.(Honors) in Pharmacology.
	1980-1981	University of London, M.Sc. in Biochemistry.
	1981-1985	University of Maryland, Ph.D. in Biological Science.
	1985-1987	Postdoctoral Fellow, National Cancer Institute, USA.

Postdoctoral Experience :

	1. Visiting Fellow at the Laboratory of Biochemistry, National Cancer Institute, National Institute of Health, U.S.A. 1985-1987 (with Maxine F. Singer)
	2. Visiting Scientist at Osaka University, Japan. 1988 (With A. Shinmyo)

List of Publications from 2003-2006:

Chauvatcharin, N., P.Vattanaviboon, J. Switala, P.C. Loewen and S. Mongkolsuk. 2003. Cloning and characterization of katA, encoding the major monofunctional catalase from Xanthomonas campestris pv. phaseoli and characterization of the encoded catalase KatA. Curr Microbiol. 46:83-87.

Vattanaviboon, P., W.Whangsuk and S.Mongkolsuk. 2003. A Suppressor of the menadione-hypersensitive phenotype of a Xanthomonas campestris pv. phaseoli oxyR Mutant reveals a novel mechanism of toxicity and the protective role of alkyl hydroperoxide reductase. J. Bacteriol. 185:1734-8.

Carpena, X., S. Loprasert, S.Mongkolsuk, J.Switala, P.C. Loewen, and I. Fita. 2003. Catalase-peroxidase KatG of Burkholderia pseudomallei at 1.7A resolution. J. Mol. Biol. 327:475-89.

Vattanaviboon, P., W.Panmanee, S. Mongkolsuk. 2003. Induction of peroxide and superoxide protective enzymes and physiological cross-protection against peroxide killing by a superoxide generator in Vibrio harveyi. FEMS Microbiol. Lett. 221:89-95

Nakjarung, K., S. Mongkolsuk and P. Vattanaviboon. 2003. The oxyR from Agrobacterium tumefaciens : evaluation of its role in the regulation of catalase and peroxide responses. Biochem. Biophys. Res. Commun. 304: 41-47.

Eiamphungporn, W., K. Nakjarung, B. Prapagdee, P.Vattanaviboon and S. Mongkolsuk 2003. Oxidant-inducible resistance to hydrogen peroxide killing in Agrobacterium tumefaciens requires the global peroxide sensor-regulator OxyR and KatA. FEMS Microbiol. Lett, 225:167-172.

Banjerdkij, P., P. Vattanaviboon and S. Mongkolsuk. 2003. Cadmium induced adaptive resistance and cross-resistance to zinc in Xanthomonas campestris. Curr. Microbiol. 47:260-262.

Vattanaviboon, P., W. Eiamphungporn and S. Mongkolsuk. 2003. Atypical adaptive and cross-protective responses against peroxide killing in a bacterial plant pathogen, Agrobacterium tumefaciens. Curr. Microbiol. 47:323-326.

Loprasert, S., W.Whangsuk, R. Sallabhan and S. Mongkolsuk. 2003. Regulation of the katG-dpsA operon and the importance of KatG in survival of Burkholderia pseudomallei exposed to oxidative stress. FEBS Lett. 542:17-21.

Loprasert, S., R. Sallabhan, W. Whangsuk and S. Mongkolsuk. 2003. Compensatory increase in ahpC gene expression and its role in protecting Burkholderia pseudomallei against reactive nitrogen intermediates. Arch. Microbiol. 180:498-502.

Prapagdee, B., P. Vattanaviboon, and S. Mongkolsuk. 2004. The role of a bifunctional catalase-peroxidase KatA in protection of Agrobacterium tumefaciens from menadione toxicity. FEMS Microbiol. Lett. 232:217-223.

Prapagdee, B., W. Eiamphungporn, P. Saenkham, S. Mongkolsuk, and P. Vattanaviboon. 2004. Analysis of growth phase regulated KatA and CatE and their physiological roles in determining hydrogen peroxide resistance in Agrobacterium tumefaciens. FEMS Microbiol Lett 237:219-226.

Loprasert, S., W. Whangsuk, R. Sallabhan, and S. Mongkolsuk. 2004. DpsA protects the human pathogen Burkholderia pseudomallei against organic hydroperoxide. Arch Microbiol 182:96-101.

Loprasert, S., W. Whangsuk, R. Sallabhan and S. Mongkolsuk. 2004. Glutathione reductase of Xanthomonas campestris: a unique enzyme and its physiological role. In: Verstraete, W. (ed), European Symposium on Environmental Biotechnology (ESEB2004), Leiden, A. A. Balkema Publishers, pp. 761-764.

Sukchawalit, R., B. Prapagdee, N. Charoenlap, P. Vattanaviboon, and S. Mongkolsuk. 2005. Protection of Xanthomonas against arsenic toxicity involves the peroxide-sensing transcription regulator OxyR. Res Microbiol 156:30-34.

Chauvatcharin, N., S. Atichartpongkul, S. Utamapongchai, W. Whangsuk, P. Vattanaviboon, and S. Mongkolsuk. 2005. Genetic and physiological analysis of the major OxyR-regulated katA from Xanthomonas campestris pv. phaseoli. Microbiology 151:597-605.

Banjerdkij, P., P. Vattanaviboon, and S. Mongkolsuk. 2005. Exposure to cadmium elevates expression of genes in the OxyR and OhrR regulons and induces cross-resistance to peroxide killing treatment in Xanthomonas campestris. Appl Environ Microbiol 71:1843-1849.

Klomsiri, C., W. Panmanee, S. Dharmsthiti, P. Vattanaviboon, and S. Mongkolsuk. 2005. Novel roles of ohrR-ohr in Xanthomonas sensing, metabolism, and physiological adaptive response to lipid hydroperoxide. J Bacteriol 187:3277-3281.

Loprasert, S., W. Whangsuk, R. Sallabhan, and S. Mongkolsuk. 2005. The unique glutathione reductase from Xanthomonas campestris: Gene expression and enzyme characterization. Biochem Biophys Res Commun 331:1324-1330.

Charoenlap, N., W. Eiamphungporn, N. Chauvatcharin, S. Utamapongchai, P. Vattanaviboon, and S. Mongkolsuk. 2005. OxyR mediated compensatory expression between ahpC and katA and the significance of ahpC in protection from hydrogen peroxide in Xanthomonas campestris. FEMS Microbiol. Lett. 249:73-78

Vattanaviboon, P., S. Utamapongchai, W. Whangsuk and S. Mongkolsuk. 2005. Important role for methionine sulfoxide reductase in the oxidative stress response in Xanthomonas campestris pv. phaseoli. J. Bacteriol. 187: 5831-5836

Mongkolsuk S., J.M. Dubbs, P.Vattanaviboon. 2005 Chemical modulation of physiological adaptation and cross-protective responses against oxidative stress in soil bacterium and phytopathogen, Xanthomonas. J Ind Microbiol Biotechnol. 32:687-90.

ChuchueT., W.Tanboon, B.Prapagdee, JM Dubbs, P.Vattanaviboon and S. Mongkolsuk. 2006 ohrR-ohr are the primary sensor/regulator and protective genes against organic hydroperoxide stress in Agrobacterium tumefaciens. J.Bacteriol. 188:842-51.

Panmanee W., P.Vattanaviboon, L. B. Poole and S. Mongkolsuk . 2006 Novel organic hydroperoxide sensing and responding mechanisms for OhrR, a major bacterial sensor and regulator of organic hydroperoxide stress. J.Bacteriol. 188:1389-95.

Whangsuk W. and S. Mongkolsuk. 2006 Analysis of mutations that alter H₂O₂ sensing and transcription regulation properties of a global peroxide regulator OxyR in Xanthomonas campestris pv. phaseoli. FEMS Microbiol Lett. 2006 257:214-20.

Hrimpeng K.,B.Prapagdee, P.Banjerdkij,P.Vattanaviboon, J.M.Dubbs, S.Mongkolsuk. 2006. Challenging Xanthomonas campestris with low levels of arsenic mediates cross-protection against oxidant killing. FEMS Microbiol Letts 262 121-127.

Eiamphungporn W., N. Charoenlap, P. Vattanaviboon, and S.Mongkolsuk 2006 Agrobacterium tumefaciens soxR is involved in superoxide stress protection and also directly regulates superoxide inducible expression of itself as well as a target gene. J.Bacteriol. In press