Dr. Skorn Mongkolsuk

 Group : Molecular and Medical Biotechnology

 

 

Contact Details :

 

Laboratory of Biotechnology
Chulabhorn Research Institute
Vibhavadee Rangsit Highway, Laksi, Bangkok 10210 THAILAND

Tel : 0-2574-0622 Fax : 0-2571-0627
E-mail :
scsmk@mahidol.ac.th

 

Position Held :

  1987-1991 Lecturer, Department of Microbiology, Mahidol University
  1990-present Head, Laboratory of Biotechnology, Chulabhorn Research Institute
  1991-1998 Assistant Professor, Department of Biotechnology, Mahidol University.
  1998-2002 Associate Professor, Department of Biotechnology, Mahidol University.
  1998-2002 Associate Faculty Member, Asian Institute of Technology.
  2002-present Professor of Biotechnology, Department of Biotechnology, Mahidol University.
  2002-present Adjunct Professor, Asian Institute of Technology
  2002-present Associate Dean for Integrated Research, Faculty of Science, Mahidol University

 

Research Interest :

 

Bacterial Molecular genetic and bacterial physiology of stress response

 

Education :

 

1977-1980

University of London, B.Sc.(Honors) in Pharmacology.

 

1980-1981

University of London, M.Sc. in Biochemistry.

  1981-1985 University of Maryland, Ph.D. in Biological Science.
  1985-1987 Postdoctoral Fellow, National Cancer Institute, USA.

 

Postdoctoral Experience :

 

1. Visiting Fellow at the Laboratory of Biochemistry, National Cancer Institute, National Institute of Health, U.S.A. 1985-1987 (with Maxine F. Singer)

 

2. Visiting Scientist at Osaka University, Japan. 1988 (With A. Shinmyo)

List of Publications from 2003-2006:

Chauvatcharin, N., P.Vattanaviboon, J. Switala, P.C. Loewen and S. Mongkolsuk. 2003. Cloning and characterization of katA, encoding the major monofunctional catalase from Xanthomonas campestris pv. phaseoli and characterization of the encoded catalase KatA. Curr Microbiol. 46:83-87. 

Vattanaviboon, P., W.Whangsuk and S.Mongkolsuk. 2003. A Suppressor of the menadione-hypersensitive phenotype of a Xanthomonas campestris pv. phaseoli oxyR Mutant reveals a novel mechanism of toxicity and the protective role of alkyl hydroperoxide reductase. J. Bacteriol. 185:1734-8.

 

Carpena, X., S. Loprasert, S.Mongkolsuk, J.Switala, P.C. Loewen, and I. Fita. 2003. Catalase-peroxidase KatG of Burkholderia pseudomallei at 1.7A resolution. J. Mol. Biol. 327:475-89.

 

Vattanaviboon, P., W.Panmanee, S. Mongkolsuk. 2003. Induction of peroxide and superoxide protective enzymes and physiological cross-protection against peroxide killing by a superoxide generator in Vibrio harveyi. FEMS Microbiol. Lett. 221:89-95

 

Nakjarung, K., S. Mongkolsuk and P. Vattanaviboon. 2003. The oxyR from Agrobacterium tumefaciens : evaluation of its role in the regulation of catalase and peroxide responses. Biochem. Biophys. Res. Commun. 304: 41-47.

Eiamphungporn, W., K. Nakjarung, B. Prapagdee, P.Vattanaviboon and S. Mongkolsuk  2003. Oxidant-inducible resistance to hydrogen peroxide killing in Agrobacterium tumefaciens requires the global peroxide sensor-regulator OxyR and KatA. FEMS Microbiol. Lett,  225:167-172.

Banjerdkij, P., P. Vattanaviboon and S. Mongkolsuk. 2003. Cadmium induced adaptive resistance and cross-resistance to zinc in Xanthomonas campestris. Curr. Microbiol. 47:260-262.

 

Vattanaviboon, P., W. Eiamphungporn and S. Mongkolsuk. 2003. Atypical adaptive and cross-protective responses against peroxide killing in a bacterial plant pathogen, Agrobacterium tumefaciens.  Curr. Microbiol. 47:323-326.

 

Loprasert, S., W.Whangsuk, R. Sallabhan and S. Mongkolsuk. 2003. Regulation of the katG-dpsA operon and the importance of KatG in survival of Burkholderia pseudomallei exposed to oxidative stress. FEBS Lett. 542:17-21.

 

Loprasert, S., R. Sallabhan, W. Whangsuk and S. Mongkolsuk. 2003. Compensatory increase in ahpC gene expression and its role in protecting Burkholderia pseudomallei against reactive nitrogen intermediates. Arch. Microbiol. 180:498-502.

 

Prapagdee, B., P. Vattanaviboon, and S. Mongkolsuk. 2004. The role of a bifunctional catalase-peroxidase KatA in protection of Agrobacterium tumefaciens from menadione toxicity. FEMS Microbiol. Lett. 232:217-223.

 

Prapagdee, B., W. Eiamphungporn, P. Saenkham, S. Mongkolsuk, and P. Vattanaviboon. 2004. Analysis of growth phase regulated KatA and CatE and their physiological roles in determining hydrogen peroxide resistance in Agrobacterium tumefaciens. FEMS Microbiol Lett 237:219-226.

 

Loprasert, S., W. Whangsuk, R. Sallabhan, and S. Mongkolsuk. 2004. DpsA protects the human pathogen Burkholderia pseudomallei against organic hydroperoxide. Arch Microbiol 182:96-101.

 

Loprasert, S., W. Whangsuk, R. Sallabhan and S. Mongkolsuk. 2004. Glutathione reductase of Xanthomonas campestris: a unique enzyme and its physiological role. In: Verstraete, W. (ed), European Symposium on Environmental Biotechnology (ESEB2004), Leiden, A. A. Balkema Publishers, pp. 761-764.

 

Sukchawalit, R., B. Prapagdee, N. Charoenlap, P. Vattanaviboon, and S. Mongkolsuk. 2005. Protection of Xanthomonas against arsenic toxicity involves the peroxide-sensing transcription regulator OxyR. Res Microbiol 156:30-34.

 

Chauvatcharin, N., S. Atichartpongkul, S. Utamapongchai, W. Whangsuk, P. Vattanaviboon, and S. Mongkolsuk. 2005. Genetic and physiological analysis of the major OxyR-regulated katA from Xanthomonas campestris pv. phaseoli. Microbiology 151:597-605.

 

Banjerdkij, P., P. Vattanaviboon, and S. Mongkolsuk. 2005. Exposure to cadmium elevates expression of genes in the OxyR and OhrR regulons and induces cross-resistance to peroxide killing treatment in Xanthomonas campestris. Appl Environ Microbiol 71:1843-1849.

 

Klomsiri, C., W. Panmanee, S. Dharmsthiti, P. Vattanaviboon, and S. Mongkolsuk. 2005. Novel roles of ohrR-ohr in Xanthomonas sensing, metabolism, and physiological adaptive response to lipid hydroperoxide. J Bacteriol 187:3277-3281.

 

Loprasert, S., W. Whangsuk, R. Sallabhan, and S. Mongkolsuk. 2005. The unique glutathione reductase from Xanthomonas campestris: Gene expression and enzyme characterization. Biochem Biophys Res Commun 331:1324-1330.

 

Charoenlap, N., W. Eiamphungporn, N. Chauvatcharin, S. Utamapongchai,  P. Vattanaviboon, and S. Mongkolsuk. 2005. OxyR mediated compensatory expression between ahpC and katA and the significance of ahpC in protection from hydrogen peroxide in Xanthomonas campestris. FEMS Microbiol. Lett. 249:73-78

 

Vattanaviboon, P., S. Utamapongchai, W. Whangsuk and S. Mongkolsuk. 2005. Important role for methionine sulfoxide reductase in the oxidative stress response in Xanthomonas campestris pv. phaseoli. J. Bacteriol. 187: 5831-5836

 

Mongkolsuk S., J.M. Dubbs, P.Vattanaviboon. 2005 Chemical modulation of physiological adaptation and cross-protective responses against oxidative stress in soil bacterium and phytopathogen, Xanthomonas. J Ind Microbiol Biotechnol. 32:687-90.

 

Chuchue T., W.Tanboon , B.Prapagdee, JM Dubbs , P.Vattanaviboon  and S. Mongkolsuk. 2006   ohrR-ohr are the primary sensor/regulator and protective genes against organic hydroperoxide stress in Agrobacterium tumefaciens. J.Bacteriol. 188:842-51.

 

Panmanee W., P.Vattanaviboon, L. B. Poole and S. Mongkolsuk . 2006 Novel organic hydroperoxide sensing and responding mechanisms for OhrR, a major bacterial sensor and regulator of organic hydroperoxide stress. J.Bacteriol. 188:1389-95.

 

Whangsuk W. and S. Mongkolsuk. 2006 Analysis of mutations that alter H2O2 sensing and transcription regulation properties of a global peroxide regulator OxyR in Xanthomonas campestris pv. phaseoli. FEMS Microbiol Lett. 2006 257:214-20.

 

Hrimpeng K.,B.Prapagdee, P.Banjerdkij,P.Vattanaviboon, J.M.Dubbs, S.Mongkolsuk. 2006. Challenging Xanthomonas campestris with low levels of arsenic mediates cross-protection against oxidant killing. FEMS Microbiol Letts 262 121-127.

 

Eiamphungporn W., N. Charoenlap, P. Vattanaviboon, and S.Mongkolsuk 2006 Agrobacterium tumefaciens soxR is involved in superoxide stress protection and also directly regulates superoxide inducible expression of itself as well as a target gene. J.Bacteriol. In press  



Last updated : 14/10/2016

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