Curriculum Vitae

NAME: Rutaiwan Tohtong
BORN: 1962, Bangkok, Thailand
POSITION: Associate Professor
AFFILIATION: Department of Biochemistry
Faculty of Science, Mahidol University
Rama VI Road, Phya Thai
Bangkok 10400, Thailand
Phone (02) 201-5606, Fax (02) 248-0375
Email: scrth@mahidol.ac.th
EDUCATION:
1983 
B.Sc. (Microbiology) Chulalongkorn University, Bangkok, Thailand. First degree honour, gold medal.
1994 
Ph.D. (Molecular Genetics) The Ohio State University, Ohio, USA. Dissertation Title: Analysis of the in vivo role of myosin regulatory light chain phosphorylation.
   
RESEARCH INTEREST:
  Mechanism of cancer metastasis
PUBLICATIONS:
1.
Tohtong, R., Yamashita, H., Graham, M., Haeberle, J., Simcox, A. and Maughan, D. (1995) Impairment of flight ability and flight muscle function caused by mutations of phosphorylation sites of myosin regulatory light chain in Drosophil. Nature 374, 650-653.
2.
Dickinson , M.H., Hyatt, C.J., Lehmann, F-O., Moore, J.R., Reedy, M.C., Simcox, A., Tohtong, R., Vigoreaux, J.O., Yamashita, H. and Maughan, D. (1997) Phosphorylation-dependent power output of transgenic flies: an integrated study. Biophys. J. 73, 3122-3134.
3.
Tohtong, R., Rodriguez, D., Maughan, D. and Simcox, A. (1997) Analysis of cDNAs encoding Drosophila melanogaster myosin light chain kinase. J. Muscle Res. Cell. Motil. 18, 43-56.
4.
Tohtong, R., Metheenukul, P. and Wilairat, P. (2002) Status of red cell membrane protein phosphorylation in thalassemia. ScienceAsia 313-317.
5.
Suthiphongchai, T., Promyart, P., Tohtong, R. and Wilairat, P. (2003). Involvement of MAP Kinase in Metastatic Development of Rat Prostatic Adenocarcinoma. Oncology Research. 13:253-259.
6.
Tohtong, R., Phattarasakul, K., Jiraviriyakul, A. and Sutthiphongchai, T. (2003) Dependence of metastatic cancer cell invasion on MLCK-catalyzed phosphorylation of myosin regulatory light chain. Prostate Cancer Prostatic Dis. 6, 212-216.
7.
Muangman, S., Thippornwong, M. and Tohtong, R. (2005) Anti-metastatic effects of curcusone B, a diterpene from Jatropha curcas.  In vivo 19, 265-268.
8.
Suthiphongchai, T., Phimsen, S., Sakulkhu, U. and Tohtong, R.  (2006) PD98059-inhibited invasion of Dunning rat prostate cancer cells involves suppression of motility but not MMP-2 or uPA secretion. Oncol. Rep. 15(6), 1605-1610.
9.
Leelawat, K., Leelawat, S., Tepaksorn, P., Rattanasinganchan, P., Leungchaweng, A., Tohtong, R. and Sobhon, P. (2006) Involvement of c-Met/Hepatocyte Growth Factor Pathway in Cholangiocarcinoma Cell Invasion and Its Therapeutic Inhibition With Small Interfering RNA Specific for c-Met. J. Surg. Res. 136, 7884.
10.
Rattanasinganchan, P., Leelawat, K., Treepongkaruna, S.A., Tocharoentanaphol, C., Subwongcharoen, S., Suthiphongchai, T. and Tohtong, R. (2006) Establishment and characterization of a cholangiocarcinoma cell line (RMCCA-1) from a Thai patient. World J. Gastroenterol 12(40), 6500-6506.
11.
Nuntagowat, C., Leelawat, K., Tohtong R. (2010) NGAL knockdown by siRNA in human cholangiocarcinoma cells suppressed invasion by reducing NGAL/MMP-9 complex formation. Clin. Exp. Metastasis. 27(5): 205-305.
12. Keeratichamroen, S., Leelawat, S., Thongtawee, T., Narong, S., Aegem, U., Tujinda, S., Praditphon, N., Tohtong, R. (2011) Expression of CD24 in cholangiocarcinoma cells is associated with disease progression and reduced patient survival. Int. J. Oncol. 39(4): 873-81.
13. Pongcharoen, P., Jinawath, A., Tohtong, R. (2011) Silencing of CD44 by siRNA suppressed invasion, migration and adhesion to matrix, but not secretion of MMPs, of cholangiocarcinoma cells. Clin. Exp. Metastasis. Epub Ahead of Print 11 Aug 2011. Doi: 10.1007/s10585-011-9414-8.
14. Thummarati, P., Wijitburaphat, S., Prasopthum, A., Menakongka, A., Sripa, B., Tohtong, R., Suthiphongchai, T. (2011) High level of urokinase plasminogen activator contributes to lymphatic invasion and metastasis of cholangiocarcinoma. World J. Gastroenterol. In press.
   

Last modified: 26-January-2012
© 2008-2009 Department of Biochemistry, Faculty of Science, Mahidol University