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Mathurose
Ponglikitmongkol |
| Associate Professor |
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| Ph.D. (Louis Pasteur, 1989) |
| Tel : +662-201-5455 |
| Fax :+662-354-7174 |
| Email : scmpl@mahidol.ac.th |
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| Research Interests :
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Molecular Biology of Cancer |
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Molecular Genetics of Infectious Diseases |
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| Current Research : |
| For years, the laboratory has focused
on the study of human diseases both genetic diseases and infectious
diseases. Recently, our main interest has emphasized on the
molecular mechanism of the genetic diseases at the gene regulation
level. Cervical cancer is still a major problem for women
worldwide including our country. Its main etiological factors
involve human papillomavirus (HPV), chemicals and genetics.
E6 and E7 are two major viral proteins produced from integrated
HPV genome influencing more than 40 types of host proteins.
Interestingly, a splice product of E6 is produced only in
cells transfected with high risk HPVs. We are interested in
examining the effects of all forms of viral proteins both
from the high risk and the low risk groups of HPVs in modulating
host protein functions. |
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| The present research in my laboratory
includes : |
| 1. The control of cellular functions
by HPV oncoproteins and hormones affecting stress and immune
response |
| 2. Gene regulation activities of
HPV oncoproteins |
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