Mathurose Ponglikitmongkol : MP's Lab

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Current projects

Cervical cancer is a major threat to the health of women worldwide. Human papillomaviruses (HPV) infection has been reported as a necessary cause of cervical cancer having type16 as a majority in high grade carcinomas.
Among various proteins produced by the viruses, E6 and E7 have been implicated in oncogenesis. Increased evidences of plethoric actions of HPV oncoproteins involving DNA replication, transcription, histone modification, cell organization and protein degradation have been shown. We are interested in determining the roles of HPV16 E6 and E7 oncoproteins in affecting the aggressiveness of cervical cancer. Alterations of gene transcription of genes involving cell proliferation, immune response and cell invasion after in vitro transfection with various types of HPV oncoproteins will be explored.


Panata's paper published in JGV 2012,93:1081-1092 has been selected by the "Global Medical Discovery" to be one of the key scientific articles important for Science and Medicine this week. This paper has also be mentioned by "Women's Health Weekly May 24th 2012"