Cervical cancer is a major threat to the
health of women worldwide. Human papillomaviruses (HPV)
infection has been reported as a necessary cause of cervical
cancer having type16 as a majority in high grade carcinomas.
Among various proteins produced by the viruses, E6 and
E7 have been implicated in oncogenesis. Increased evidences
of plethoric actions of HPV oncoproteins involving DNA
replication, transcription, histone modification, cell
organization and protein degradation have been shown.
We are interested in determining the roles of HPV16 E6
and E7 oncoproteins in affecting the aggressiveness of
cervical cancer. Alterations of gene transcription of
genes involving cell proliferation, immune response and
cell invasion after in vitro transfection with various
types of HPV oncoproteins will be explored.