Biological systems are dependent
upon a complex array of interactions between various metabolic
pathways in the cells. Dysregulation of some key enzymes
leading to the impairment of certain pathways can lead to
metabolic disturbance or diseases. We are a very well-established
group of modern metabolism. Our research group on metabolic
biochemistry has been focusing on the studies of the enzymes
involved in glucose, lipid and xenobiotic metabolisms. We
employ novel state-of-the-art molecular approaches including
basic protein biochemistry, cell biology, cell-based assay,
reporter gene analysis, DNA-protein interaction assay, siRNA,
quantitative real time PCR to investigate the regulation
of these important metabolic enzymes at the cellular and
molecular levels. The specific projects ongoing within this
group are |
