Bacterial infection remains one of the most
serious causes of human death even though several groups of
antibiotic have been developed in the past decades. Production
of virulence factors from bacteria appears to be a key factor
to overcome hostís immune surveillance. Current research activity
in the molecular and biochemistry of pathogenic bacteria is
mainly centered on the molecular mechanism underlying the
pathogenesis of infection caused by Burkholderia bacteria.
This bacterial infection is the causative agent of Melioidosis,
a disease that found mostly in the tropical area including
Thailand. We have employed system biology techniques including
proteomics, transcriptome analysis, gene knockout and bioinformatics
aiming to identify the key genes in the bacterial genome,
that are important for bacterial pathogenesis. These informations
will allow us to develop vaccine or new therapeutic agents
to fight against this bacteria.
Pathogenic Clostridium spp.
Members of bacteria in the genus Clostridium are anaerobic spore-forming rod-shaped bacteria. They exist as either free-living bacteria as well as pathogens which infect both humans and animals. Most pathogenic Clostridium species are known to produce toxins, which are responsible for a wide range of diseases. In Thailand, the knowledge about Clostridium spp. is very limited due to difficulty in isolation and identification. We aim to gain more information on these bacterial species in Thailand.