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Center for Excellence in Protein Structure and Function (CPSF)

 

GENERAL INFORMATION

 

As is well known, genetic information contained in the DNA sequences of the genome must be expressed as proteins before they can perform their designated functions. These proteins must fold into their specific three-dimensional structures that determine how they function. In addition, some proteins may be chemically modified after synthesis or converted from inactive to active forms. Moreover, different proteins may be synthesized in different tissues, or at different stages of development or in disease states. Thus, the complete understanding of living processes requires understanding of structure and function relationships in proteins. Thus, the "Center for Protein Structure and Function (CPSF)" was founded as a Center for Excellence of Faculty of Science, Mahidol University 2001, to serve as an interdisciplinary research laboratory for elucidating the molecular basis of protein action and its relationship with three-dimensional structure. Staff in the Center come from various departments, namely Professor M.R. Jisnuson Svasti (Head), Dr. Jirundon Yuvaniyama and Dr. Pimchai Chaiyen from the Biochemistry Department, Dr. Palangpol Kongsaeree from the Chemistry Department, and Dr. Pramvadee Wongsaengchantra from the Biotechnology Department. In addition, Professor William N. Lipscomb, Nobel Laureate in Chemistry from Harvard University, is an advisor to the Center, and was attached to the Center between June to September 2002, as the first Stang Mongkolsuk Distinguished Professor of the Faculty of Science, Mahidol University.

 

The Faculty of Science has provided CPSF with modern sophisticated equipment, including X-ray diffractometer system for studying the three-dimensional structure of proteins and stopped-flow spectrophotometry for studying enzyme mechanisms, as well as FPLC, HPLC, spectrophotometers and other equipment. Operational budget comes from several grants awarded to CPSF staff, by various agencies, such as Mahidol University, Thailand Research Fund and BIOTEC. The complementary expertise of staff members and state-of-the-art equipment enables CPSF to use a combination of structural biology, protein biochemistry, and mechanistic enzymology to study protein structure-function relationships and explore interesting problems at the interface of biochemistry and chemistry.

 

 STAFF AND RESEARCH OF INTERESTS

 

 

Prof. M.R. Jisnuson Svasti (Head)

- Protein chemistry and enzymology of Glucosidases from Thai plants
- Proteins and Proteomics of Cancer
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Dr. Jirundon Yuvaniyama

- X-ray Crystallography and Protein Engineering of dihydrofolate reductase,Thymidylate synthase from Plasmodium falciparum, Plasmepsin from Plasmodium sp., penicillin G acylase from B. megaterium, P450 and flavin- containing enzymes
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Assoc. Prof. Palangpon Kongsaeree

- X-ray Crystallography of Glucosidases, dihydrofolate reductase-Thymidylate synthase from Plasmodium vivax
- Identification of targets of bioactive compounds using proteomics
- Protein-linked nanoparticles
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Assoc. Prof. Pimchai Chaiyen

- Mechanisms and Structures of flavin and pyridoxal phosphate dependent enzymes: p-hydroxyphenylacetate hydroxylase, pyranose oxidase, bacterial luciferase, and serine hydroxymethyl transferase
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Dr. Pramvadee Y. Wongsaengchantra

- Application of sericin-specific proteinase in silk degumming process
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Dr. Kittisak Yokthongwattana

– Proteins in protection and repair of Photosystem II
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CONTACT ADDRESS :

Center for Excelllence in Protein Structure and Function,
Chalermprakiat Building, Floor 4
Faculty of Science, Mahidol University
Rama VI Road, Bangkok 10400, Thailand
Tel : (66)2 201 5845 (Head); (66)2 201 5840 (Secretary)
Fax
: (66)-02-201-5843
E-mail : jisnuson.sva@mahidol.ac.th
Website : http://www.sc.mahidol.ac.th/research/protein.htm