 |
|
 |
| |
|
|
|
|
| |
|
| |
| |
| CONSORTIUM
FOR CALCIUM AND BONE RESEARCH (COCAB)
|
|
Website: http://www.cocab.mahidol.ac.th |
| |
 Main
Objectives :
Our interdisciplinary research focuses on
study of calcium metabolism in health and
disease, from the whole body level to molecular
level in three major organs, that is, intestine,
bone and mammary gland. We study the cellular
and molecular mechanisms of the intestinal
calcium transport, mammary calcium transport
and regulation of bone remodeling by using
in vivo and in vitro techniques to cover
various levels of organization from whole
body, organ, tissue, cellular, and molecular
level. By using an interdisciplinary approach,
we investigate the biophysical and physiological
characteristics of calcium transport in
the intestinal epithelium in certain conditions
such as pregnancy and lactation. We also
investigate the effects of exercise on calcium
absorption and gene expression of calcium
transporters and tight junction-associated
proteins that are important regulators of
the paracellular transport of calcium.
We also study some medical conditions that
result in deranged calcium metabolism in
Thai patients such as chronic metabolic
acidosis (CMA) and postmenopausal osteoporosis
and how intestinal calcium transport mechanism
and bone remodeling are altered is these
conditions.
Head
of the Center :
Prof. Nateetip Krishnamra, Ph.D.
Research Area/
Research Interest :
1. Prolactin
: its role as a calcium regulating hormone
2. Prolactin
and electrolyte transport in the endometrium
3. Signal
transduction pathways of prolactin
4.
Cellular and molecular mechanism of the
intestinal calcium absorption and possible
role of claudins in the paracellular calcium
transport
5.
Disorders of calcium and bone metabolism
in metabolic bone diseases
6.
How nonimpact exercise affect calcium absorption
and bone remodeling
7.
How brain controls bone
8.
Use of Atomic Force Microscopy and Nanoindentation
in the study of physical and mechanical
properties of bone
|
CONTACT ADDRESS
Consortium for Calcium and Bone Research
(COCAB)
Room Pr. 405, Pr. Building
Faculty of Science, Mahidol University
Rama 6 Road, Bangkok 10400 Thailand
Tel : +66 2201-5629 Fax
: +66 2354-7154
E-mail
: scnks@mahidol.ac.th
Website: http://www.cocab.mahidol.ac.th
|
|
|
| |
|
|
|
 |
Last modified:18-Nov-2008
© 2008 Faculty of Science, Mahidol University
|
272 Rama VI Road,
Ratchathewi District, Bangkok 10400, THAILAND
Tel: +66 2201-5007 Fax: +66 2354-7165
Webmaster : scwww@mahidol.ac.th |
|
|
|
|
 |
|
 |
|
